Imagine surgery without a scar

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Dr. Longkerr with passion in 1987 at the University of California at San Francisco, Dr. Michael R. The experiment began as a new postdoctoral fellow in Harrison’s laboratory. Dr. Harrison, who was studying fetal surgery, suggested that Drs. Longecker performs a fetal lamb operation two-thirds of the way through pregnancy and then sends the fetus back to her mother’s womb to continue development.

Dr. Longekar gasped when he later delivered the baby lamb. Its skin was intact. If seen, there were no stains.

“I’ll never forget that moment,” he said.

He became a pediatric plastic surgeon and saw for the first time that the children had their lip or palate operation after the scar. And he ran a lab dedicated to figuring out how to stop the trail.

He learned that for the first two trimesters of fetal life, the skin is gelatinous, “like a bowl of Jell-O” Dr. Longecker said. Then, as the fetus develops to live outside the sterile liquid world of the womb, the skin forms a barrier to prevent water loss and block the entry of microorganisms. At that point, a breach of the skin barrier can be fatal, so the body switches to a system that allows it to seal quickly.

But there is a trade-off for speed in healing a wound, Drs. Longecker said. “Cost is a loss of form and function.” And scar formation.

Dr. Tomic-Canic has described this process: When a wound occurs, the strong muscle under the skin contracts and brings together the edges of the wound. A clot forms as a temporary barrier above the wound, and under it, the body forms coarse coils of collagen rope that form a bridge so that skin cells can migrate during the gap and fill in the opening. They remain collagen ropes – they are scars.

As advanced molecular biology and molecular genetics, Drs. Longaker captured new equipment to investigate the molecular pathways required to make the mark. The critical starting point for a stain is mechanical stress when a wound tears the skin that needs to be taut. (Older people with loose skin are less likely to get scars because their skin is less stressed.) Tears in the skin folds signal a type of skin cell – fibroblasts – to form collagen rope and molecular events inside. Let’s start the chain reaction. skin cells. Activation of a protein called YAP for Yes-associated proteins culminates in the reactions. The YAP then joins the DNA, and traces begin.

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